Traditional semen analysis often fails to detect the "hidden" genetic defects that lead to idiopathic infertility and broader male infertility. Sperm DNA fragmentation represents a critical barrier to successful fertilization and healthy embryo development. Even in patients with "normal" routine parameters, high DNA fragmentation is a primary driver of recurrent pregnancy loss, miscarriage, and IVF failure. Elevated DFI is a key biomarker of oxidative stress in semen; quantify it with the NBT Assay. The SCD Assay helps identify this hidden cause of male infertility.
.webp)
 2.webp)
Sperm DNA Fragmentation Test Kit (SCD Assay)
Advanced Genetic Integrity Assessment via Sperm Chromatin Dispersion (SCD) Technology
The Science of Genetic Health:
The Sperminfo® Engineering Advantage:
Our SCD Assay utilizes a proprietary slide-based technology designed to eliminate laboratory variability:
Precision Engineering: Ultra-hydrophobic Teflon-coated slides provide superior sample control, preventing cross-contamination and droplet spreading.
Dimensional Stability: A 20-micron thick proprietary coating ensures optimal reaction volume, providing a stable and reproducible environment for chromatin dispersion.
Secure Capture: Specially treated adhesive wells anchor spermatozoa firmly in place, preventing cell loss during the acid denaturation and lysis phases.
Key Features:
Visual Confidence: Produces a robust and significant "Halo" effect, making result interpretation unambiguous.
Rapid Turnaround: Complete reaction cycle in approximately 25 minutes, significantly faster than TUNEL or SCSA protocols.
Long-term Stability: Formulated for long-term room-temperature storage, reducing cold-chain reliance.
Clinical Reference: Validated against the WHO Laboratory Manual (6th Edition) standards for specialized diagnostic testing.
References
- WHO (2021). WHO Laboratory Manual for the Examination and Processing of Human Semen, 6th Edition.
- Fernández JL, et al. (2003). The Sperm Chromatin Dispersion (SCD) test: a simple method for the determination of sperm DNA fragmentation. Fertility and Sterility.
- Evenson DP, et al. (2002). Characteristics of human sperm chromatin structure and its association with fertility. Journal of Andrology.